- Ensure effective coordination and management of the decentralized, multi sectoral national response to HIV
- Develop and implements a National Strategic Framework for planning, implementing, monitoring, and evaluating all HIV and AIDS programs through a multi sectoral approach;
- Mobilizes, expends, and coordinate resources through an efficient allocation system;
- Plays a lead advocacy role for the prevention and control of HIV and AIDS;
- Creates strategic linkages among national and international stakeholders in a coordinated response to HIV and AIDS;
- Collects, analyzes, disseminates, and shares information on HIV and AIDS and its consequences;
- Promulgate rules providing protocols for counseling, testing, caring, supporting, and treatment for all members of Most at Risk Populations;
- Promotes research, information sharing and documentation on HIV and AIDS prevention and control;
- Develops policies to respond to the HIV and AIDS pandemic and manage its impact in Liberia;
- Promotes positive living of people with HIV and AIDS;
- Protects communal rights of people infected with and affected by HIV and AIDS;
- Advises the government on all matters relating to the prevention and control of HIV and AIDS